Neurogenesis

The birth of new neurons from stem cells, and what helps or hinders it in the adult brain

NeuroscienceProtocol Glossary

In plain English

The short version, before the science.

The adult brain can grow new nerve cells from stem cells, mainly in the hippocampus. This runs at a high rate before birth and at a much lower rate later in life. The hippocampus handles learning and memory.

Key takeaways

Three things to remember

  1. 01

    Neurogenesis is the growth of new neurons from stem cells, and in adults it is concentrated in the hippocampus.

  2. 02

    Aerobic exercise and sleep support it, while chronic stress and heavy drinking suppress it, mostly shown in animal studies.

  3. 03

    How much neurogenesis occurs in adult humans is still debated, so you cannot measure it and should not expect a quick fix.

How it works

The Mechanism

Neurogenesis starts with neural stem cells that divide into young neurons. Those young cells migrate a short distance, grow branches, and wire themselves into existing circuits. In adults, the best-studied site is the dentate gyrus, a strip of tissue inside the hippocampus. Newly formed neurons there are unusually excitable for the first few weeks, and researchers think this helps the brain tell similar memories apart, such as where you parked today versus yesterday.

The process responds to lifestyle. Aerobic exercise raises BDNF, a protein that supports the survival and growth of young neurons, and running consistently increases new neuron counts in animal studies. Chronic stress works in the opposite direction: sustained high cortisol reduces the rate at which new neurons are produced. Sleep loss and heavy alcohol use also suppress it in animal models.

One honest caveat: how much neurogenesis continues in the adult human brain is still debated. Some studies of human tissue find new neurons well into later life, while others find very few after childhood. The animal evidence is strong, but the human numbers are less settled, so treat claims about growing a bigger brain with caution.

In practice

Why It Matters

You cannot measure it, but the habits that support it are well established.

Neurogenesis is one of the main reasons researchers believe the adult brain stays adaptable. The habits that appear to support it, regular aerobic exercise, enough sleep, and managing chronic stress, are the same ones linked to better memory and mood in people. You cannot measure your own neurogenesis, so the practical use is as a reason to protect those habits rather than a number to chase.

Common misconception

Many people say you are born with all the neurons you will ever have, or the opposite, that supplements and brain games reliably grow new ones. Neither is accurate. The adult brain does appear to add some new neurons in the hippocampus, but the rate is low, its size in humans is debated, and the best-documented drivers are exercise, sleep, and lower chronic stress rather than any product.

What moves it

How to Improve It

  1. Aerobic exercise. Aim for 150 minutes per week of moderate aerobic activity, such as brisk walking or easy cycling. Exercise raises BDNF, the most consistent driver of new neuron growth in animal studies.

  2. Protect sleep. Aim for 7 to 9 hours per night on a regular schedule. Sleep loss suppresses new neuron production in animal models and impairs the memory processing those neurons support.

  3. Lower chronic stress. Build a daily downshift habit of 10 to 20 minutes, such as a walk or slow breathing. Sustained high cortisol reduces new neuron production, so reducing its weekly load matters.

  4. Keep alcohol low. Limit drinking to a few drinks per week or fewer. Heavy alcohol intake reduces new neuron survival in animal studies, and it also fragments sleep.

  5. Learn something demanding. Practice a new skill for 20 to 30 minutes several times a week. Learning appears to help newly formed neurons survive long enough to join working circuits.

Go deeper

Appears In